Friday, December 26, 2008

I got one... a great one!

Influence of MMP on Brain AVM Hemorrhage
This study is currently recruiting participants.
Verified by University of California, San Francisco, October 2008
Sponsored by: University of California, San Francisco
Information provided by: University of California, San Francisco Identifier: NCT00783523

Brain vascular malformations, including arteriovenous malformations (AVM), cavernous malformations (CVM) and aneurysms, are a source of life-threatening risk of intracranial hemorrhage. The etiology and pathogenesis are unknown. There is no medical therapy presently available. Prevention of spontaneous intracerebral hemorrhage (ICH) is the primary reason to treat brain vascular malformations. The goal of this study is to: begin pilot studies to lay the groundwork for future clinical trials to develop medical therapy to decrease ICH risk.

Matrix metalloproteinases (MMPs) regulate the extracellular matrix in association with various hemorrhagic brain disorders. MMP-9 has been most consistently associated with vascular wall instability and hemorrhagic brain disorders. Doxycycline, a non-specific MMP inhibitor, may enhance vascular stability, thus reducing the risk of spontaneous hemorrhage in brain vascular malformations by decreasing MMP-9 activity.




I've been looking for a clinical study to join. I am so sick of not knowing what to say, when in a conversation. This one doesn't cover that, but it shows that I'm on the right track.

So did you have a good Christmas!
I hope so.
okay, I gotta go.

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